Biomaterials for Stem Cell Morphogenesis
Promoting blood and lymphatic vasculature is important for tissue engineering and can be used as therapeutic interventions to treat ischemia and lymphedema.
We are studying the role of growth factors and extracellular matrices (ECMs) in blood and lymphatic vessel formation. We utilize bio-mimetic materials with spatial and temporal control for stem cells to undergo morphogenesis into vascular and lymphatic vasculatures.
We are applying this approach toward therapeutic interventions to treat ischemia and wound healing in animal models.
Selected Publications:
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Matrix Stiffness Primes Lymphatic Tube Formation Directed by Vascular Endothelial Growth Factor-C.
Laura Alderfer, Elizabeth Russo, Adriana Archilla, Brian Coe, Donny Hanjaya-Putra; FASEB Journal, 2021 March. PDF -
Lymphatic Tissue Engineering and Regeneration
Laura Alderfer, Alicia Wei, Donny Hanjaya-Putra; Journal of Biological Engineering, 2018 Dec 17; 12.32. PDF -
Spatial Control of Cell-Mediated Degradation to Regulate Vasculogenesis and Angiogenesis in Hyaluronan Hydrogels
Donny Hanjaya-Putra, Kyle T. Wong, Kelsey Hirotsu, Sudhir Khetan, Jason A. Burdick, Sharon Gerecht; Biomaterials, 2012, Sep; 33(26):6123-31. PDF -
Controlled Activation of Morphogenesis to Generate a Functional Human Microvasculature in a Synthetic Matrix
Donny Hanjaya-Putra, Vivek Bose, Yu-I Shen, Jane Yee, Sudhir Khetan, Karen Fox-Talbot, Charles Steenbergen, Jason A. Burdick, Sharon Gerecht; Blood, 2011, Jul 21; 118(3):804-15. PDF
Researchers
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Laura Alderfer
Ph.D. Student, Bioengineering Graduate Program
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Fei Fan
Postdoc, Department of Aerospace and Mechanical Engineering
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Eva Hall
Ph.D. Student, Bioengineering Graduate Program
Collaborators
Dr. Matthew Webber
Chemical and Biomolecular Engineering
Dr. Jason A. Burdick
Bioengineering, University of Pennsylvania
Support from:
