Biomaterials for Stem Cell Morphogenesis
Promoting blood and lymphatic vasculature is important for tissue engineering and can be used as therapeutic interventions to treat ischemia and lymphedema.
We are studying the role of growth factors and extracellular matrices (ECMs) in blood and lymphatic vessel formation. We utilize bio-mimetic materials with spatial and temporal control for stem cells to undergo morphogenesis into vascular and lymphatic vasculatures.
We are applying this approach toward therapeutic interventions to treat ischemia and wound healing in animal models.
Lymphatic Tissue Engineering and Regeneration
Laura Alderfer, Alicia Wei, Donny Hanjaya-Putra; Journal of Biological Engineering, 2018 Dec 17; 12.32. PDF
Spatial Control of Cell-Mediated Degradation to Regulate Vasculogenesis and Angiogenesis in Hyaluronan Hydrogels
Donny Hanjaya-Putra, Kyle T. Wong, Kelsey Hirotsu, Sudhir Khetan, Jason A. Burdick, Sharon Gerecht; Biomaterials, 2012, Sep; 33(26):6123-31. PDF
Controlled Activation of Morphogenesis to Generate a Functional Human Microvasculature in a Synthetic Matrix
Donny Hanjaya-Putra, Vivek Bose, Yu-I Shen, Jane Yee, Sudhir Khetan, Karen Fox-Talbot, Charles Steenbergen, Jason A. Burdick, Sharon Gerecht; Blood, 2011, Jul 21; 118(3):804-15. PDF