Biomaterials for Stem Cell Morphogenesis


Promoting blood and lymphatic vasculature is important for tissue engineering and can be used as therapeutic interventions to treat ischemia and lymphedema.

Biomaterials for stem cell morphogenesis research


We are studying the role of growth factors and extracellular matrices (ECMs) in blood and lymphatic vessel formation. We utilize bio-mimetic materials with spatial and temporal control for stem cells to undergo morphogenesis into vascular and lymphatic vasculatures.

We are applying this approach toward therapeutic interventions to treat ischemia and wound healing in animal models.

Bio scans

Selected Publications:

  1. Matrix Stiffness Primes Lymphatic Tube Formation Directed by Vascular Endothelial Growth Factor-C. 
    Laura Alderfer, Elizabeth Russo, Adriana Archilla, Brian Coe, Donny Hanjaya-Putra; FASEB Journal, 2021 March.  PDF

  2. Lymphatic Tissue Engineering and Regeneration 
    Laura Alderfer, Alicia Wei, Donny Hanjaya-Putra; Journal of Biological Engineering, 2018 Dec 17; 12.32. PDF

  3. Spatial Control of Cell-Mediated Degradation to Regulate Vasculogenesis and Angiogenesis in Hyaluronan Hydrogels
    Donny Hanjaya-Putra, Kyle T. Wong, Kelsey Hirotsu, Sudhir Khetan, Jason A. Burdick, Sharon Gerecht; Biomaterials, 2012, Sep; 33(26):6123-31. PDF

  4. Controlled Activation of Morphogenesis to Generate a Functional Human Microvasculature in a Synthetic Matrix
    Donny Hanjaya-Putra, Vivek Bose, Yu-I Shen, Jane Yee, Sudhir Khetan, Karen Fox-Talbot, Charles Steenbergen, Jason A. Burdick, Sharon Gerecht; Blood, 2011, Jul 21; 118(3):804-15. PDF


  • Laura Alderfer

    Ph.D. Student, Bioengineering Graduate Program

  • Fei Fan

    Postdoc, Department of Aerospace and Mechanical Engineering

  • Eva Hall

    Ph.D. Student, Bioengineering Graduate Program


Dr. Matthew Webber 
Chemical and Biomolecular Engineering 

Dr. Jason A. Burdick
Bioengineering, University of Pennsylvania

Support from:

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American Heart Association

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