Targeted Drug Delivery

Hand

Many available drugs are effective at a very small therapeutic window without causing systemic side effects. For example, anti-coagulant drugs are effective at preventing blood clot, but can also cause systemic bleeding. To overcome these limitations, we are interested in harnessing the ability of stem cell and antibody for site-specific delivery of therapeutics.

Targeted Drug Delivery Research

Selected Publications

  1. Platelet-targeted dual pathway antithrombotic inhibits thrombosis with preserved hemostasis.
    Donny Hanjaya-Putra, Carolyn Haller, Xiaowei Wang, Erbin Dai, Bock Lim, Liying Liu, Patrick Jaminet, Joy Yao, Amy Searle, Thomas Bonnard, Christoph E. Hagemeyer, Karlheinz Peter, and Elliot L. Chaikof; JCI Insight, 2018 Aug; 3(15):e99329. PDF

  2. Glycopeptide analogues of PSGL-1 inhibit P-selectin in vitro and in vivo
    Venkata R. Krishnamurthy, Mohammed Y.R. Sardar, Yu Ying, Xuezheng Song, Carolyn Haller, Erbin Dai, Xiaocong Wang, Donny Hanjaya-Putra, Lijun Sun, Vasilios Morikis, Scott I. Simon, Robert J. Woods, Richard D. Cummings, Elliot L. Chaikof; Nature Communications, 2015 Mar 31: 6:6387. PDF

Researchers

  • Fei Fan

    Postdoc, Department of Aerospace and Mechanical Engineering

  • Eva Hall

    Ph.D. Student, Bioengineering Graduate Program

Collaborators

Dr. Laura S. Haneline
Indiana University School of Medicine

Support from:

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