Targeted Drug Delivery

Many available drugs are effective at a very small therapeutic window without causing systemic side effects. For example, anti-coagulant drugs are effective at preventing blood clot, but can also cause systemic bleeding. To overcome these limitations, we are interested in harnessing the ability of stem cell and antibody for site-specific delivery of therapeutics.

Selected Publications

1. Engineering Bioactive Nanoparticles to Rejuvenate Vascular Progenitor Cells. Loan Bui, Shanique Edwards, Eva Hall, Laura Alderfer, Kellen Round, Madeline Owen, Pietro Sainaghi, Siyuan Zhang, Prakash Nallathamby, Laura S. Haneline, Donny Hanjaya-Putra. Communications Biology, 2022 June. PDF

2. Platelet-targeted dual pathway antithrombotic inhibits thrombosis with preserved hemostasis.
   Donny Hanjaya-Putra, Carolyn Haller, Xiaowei Wang, Erbin Dai, Bock Lim, Liying Liu, Patrick Jaminet, Joy Yao, Amy Searle, Thomas Bonnard, Christoph E. Hagemeyer, Karlheinz Peter, and Elliot L. Chaikof; JCI Insight, 2018 Aug; 3(15):e99329. PDF

3. Glycopeptide analogues of PSGL-1 inhibit P-selectin in vitro and in vivo
   Venkata R. Krishnamurthy, Mohammed Y.R. Sardar, Yu Ying, Xuezheng Song, Carolyn Haller, Erbin Dai, Xiaocong Wang, Donny Hanjaya-Putra, Lijun Sun, Vasilios Morikis, Scott I. Simon, Robert J. Woods, Richard D. Cummings, Elliot L. Chaikof; Nature Communications, 2015 Mar 31: 6:6387. PDF