Stem Cell Engineering
Stem cells have the potential to induce repair and participate in regenerating injured tissues. However, during the course of chronic diseases (e.g., cardiovascular diseases and diabetes) and aging, resident and circulating stem cells are subject to stress-induced premature dysfunction that limits their therapeutic use. Our lab is interested to utilize engineering approaches to understand the mechanisms governing stem cell fate and to control stem cell differentiation, in particular for their therapeutic application in cardiovascular and lymphatic disorders.
Self-Organized Vascular Networks from Human Pluripotent Stem Cells in a Synthetic Matrix
Sravanti Kusuma, Yu-I Shen, Donny Hanjaya-Putra, Prashant Mali, Linzhao Cheng, Sharon Gerecht; Proc Natl Acad Sci U S A, 2013 Jul 30; 110(31): 12601-6. PDF
The Differential Formation of the LINC-mediated Perinuclear Actin Cap in Pluripotent and Somatic Cells
Shyam B. Khatau, Sravanti Kusuma, Donny Hanjaya-Putra, Prashant Mali, Linzhao Cheng, Jerry S.H. Lee, Sharon Gerecht, Denis Wirtz; PLoS ONE, 2012, 7(5):e36689. PDF